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Briefings in Functional Genomics and Proteomics Advance Access published online on April 28, 2008
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/eln019
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© The Author 2008. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

Studying gene function in Caenorhabditis elegans using RNA-mediated interference

Eleanor M. Maine

Corresponding author. Eleanor M. Maine, Department of Biology, Syracuse University, Syracuse, NY 13244, USA. E-mail: emmaine{at}syr.edu

The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.

Keywords: Caenorhabditis elegans, RNA, functional genomics, gene networks, gene interaction


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