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Briefings in Functional Genomics and Proteomics Advance Access published online on July 28, 2006
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/ell028
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© Oxford University Press, 2006, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Original Article

Histone acetylation in gene regulation

Loredana Verdone, Eleonora Agricola, Micaela Caserta, and Ernesto Di Mauro *

* To whom correspondence should be addressed.
Ernesto Di Mauro, E-mail: ernesto.dimauro{at}uniroma1.it


  Abstract

Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells.

This review focuses on the role of enzymes involved in controlling both histone and non-histone proteins acetylation levels in the cell, with particular emphasis on their effects on cancer.

Keywords: nucleosomes; gene expression; acetylation; deacetylation; cancer.

Loredana Verdone, PhD in Genetics and Molecular Biology from the University of Rome (1997), completed her training in Molecular Biology with Prof. J. Beggs at the Institute of Cell and Molecular Biology, University of Edinburgh. Since 2005, she has been researcher at the IBPM-CNR, University ‘La Sapienza’, Rome.

Eleonora Agricola received the degree in Biological Sciences from the University of Rome in 2003. A PhD candidate in Pasteurian Science at University ‘La Sapienza’ of Rome, her research interest focuses on epigenetics and gene regulation.

Micaela Caserta received the degree in Biological Sciences in 1982 and the PhD in Genetics and Molecular Biology (1987) at the university of Rome. Since 1989 she is Researcher of the IBPM-CNR, University ‘La Sapienza’, Rome.

Ernesto Di Mauro received the degree in Biological Sciences from the University of Rome in 1967. Professor of Molecular Biology at the University of Rome ‘La Sapienza’ since 1987, he is currently the Scientific Director of the Foundation ‘Pasteur-Cenci Bolognetti’.


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