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Briefings in Functional Genomics and Proteomics Advance Access published online on February 24, 2006
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/ell013
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© Oxford University Press, 2006, All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org

Paper

Organization of brain complexity--synapse proteome form and function

A. J. Pocklington, J. D. Armstrong, and S. G. N. Grant *

* To whom correspondence should be addressed.
S. G. N. Grant, E-mail: sg3{at}sanger.ac.uk


  Abstract

Proteomic study of the synapse has generated an extensive list of molecular components, revealing one of the most complex functional systems currently known to cell biology. While fundamental to neural information processing, behaviour and disease, the molecular organisation of the synapse and its relation to higher-level function has yet to be clearly understood. Neurotransmitter receptor complexes, such as the N-methyl-D-aspartate receptor complex (NRC/MASC), are major components of the synaptic proteome. We have recently completed a detailed study of MASC, its functional organisation and involvement in behaviour and disease. This pointed to simple design principles underlying synaptic organisation. Drawing together the results of proteomic and analytical study, we sketch out a model for synaptic functional organisation.

Keywords: LTP; NMDA receptor; protein complex; synaptic plasticity; networks.

Andrew Pocklington is a Research Fellow at the Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh.

J. Douglas Armstrong is the Deputy Director of the Edinburgh Centre for Bioinformatics at the University of Edinburgh.

Seth G. N. Grant is the Director of the Genes to Cognition Program at the Wellcome Trust Sanger Institute, Cambridgeshire.


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