Skip Navigation



Briefings in Functional Genomics and Proteomics Advance Access published online on February 23, 2006
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/ell002
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
5/1/74    most recent
ell002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gindhart, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gindhart, J. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Oxford University Press, 2006, All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org

Paper

Towards an understanding of kinesin-1 dependent transport pathways through the study of protein-protein interactions

Joseph G. Gindhart *

* To whom correspondence should be addressed.
Joseph G. Gindhart, E-mail: jgindhar{at}richmond.edu


  Abstract

Kinesin-1 is the founding member of a superfamily of motor proteins that transport macromolecules along microtubules in an ATP-dependent manner. Classic studies show that kinesin-1 binds to intracellular cargos through non-covalent interactions with proteins on the cargo surface, that protein-protein interaction domains are present in the cargo-binding tail domain and that phosphorylation-dependent signal transduction pathways regulate kinesin-cargo interactions. A combination of genetics, biochemistry and proteomics has identified processes in which kinesin-1 has an important role, and helped reveal the mechanisms of kinesin-dependent transport events. These approaches have identified more than 35 proteins that bind to kinesin-1; these proteins act as cargos, cargo receptors and regulators of kinesin-1 activity. This review summarizes our current understanding of kinesin-1 associated proteins, and places those protein-protein interactions into the context of kinesin-1 in vivo function.

Keywords: kinesin; microtubule motors; intracellular transport; yeast two-hybrid system; mass spectrometry; genetic interaction screens.

Joseph G. Gindhart is an associate professor in the Biology Department at the University of Richmond. His research interests are identifying the functions of Drosophila kinesin-1 and the mechanisms of kinesin-cargo attachment.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
D. D. Hackney
Jump-starting kinesin
J. Cell Biol., January 1, 2007; 176(1): 7 - 9.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.