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Briefings in Functional Genomics and Proteomics Advance Access published online on February 22, 2006
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/ell001
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© Oxford University Press, 2006, All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org

Paper

Multi-protein complexes at the {beta}-globin locus

Milind C. Mahajan and Sherman M. Weissman *

* To whom correspondence should be addressed.
Sherman M. Weissman, E-mail: Sherman.weissman{at}yale.edu


  Abstract

Biochemical analysis of the {beta}-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the {beta}-globin gene expression.

Keywords: {beta}-globin; LCR; SWI/SNF; MeCP1; CTCF; hnRNP C1/C2; GATA-1; NF-E2; EKLF.

Milind C. Mahajan is an Associate Research Scientist in Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

Sherman M. Weissman is a Sterling Professor of Genetics and Medicine at Yale University School of Medicine. He is the Co-Director of the Molecular Oncology and Development Program at the Yale Cancer Center, and Co-Director of Yale's Center for Excellence in Genomic Science.


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