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Briefings in Functional Genomics and Proteomics Advance Access originally published online on June 25, 2008
Briefings in Functional Genomics and Proteomics 2008 7(4):239-248; doi:10.1093/bfgp/eln027
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Systems biology at the Institute for Systems Biology

Leroy Hood, Lee Rowen, David J. Galas and John D. Aitchison

Corresponding author. Lee Rowen, Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103, USA. Tel: (206) 732-1271; Fax: (206)732-1299; E-mail: lrowen{at}systemsbiology.org

Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and/or mathematically to generate mechanistic explanations for the emergent systems properties. This requires that the biological frontiers drive the development of new measurement and visualization technologies and the pioneering of new computational and mathematical tools—all of which requires a cross-disciplinary environment composed of biologists, chemists, computer scientists, engineers, mathematicians, physicists, and physicians speaking common discipline languages. The Institute for Systems Biology has aspired to pioneer and seamlessly integrate each of these concepts.

Keywords: system, complexity, computation, networks, modeling, technology development


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