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Briefings in Functional Genomics and Proteomics Advance Access originally published online on June 19, 2008
Briefings in Functional Genomics and Proteomics 2008 7(3):228-235; doi:10.1093/bfgp/eln024
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Caenorhabditis elegans: Ten Years After the Genome [View the issue table of contents]

Special Issue Papers

Functional genomic, computational and proteomic analysis of C. elegans microRNAs

Nicolas J. Lehrbach and Eric A. Miska

Corresponding author. Eric A. Miska, Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. E-mail: eam29{at}cam.ac.uk

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in many eukaryotes. miRNAs were first discovered in Caenorhabditis elegans by Victor Ambros’ laboratory in 1993. At the same time Gary Ruvkun's laboratory identified the first miRNA target gene. Together, these two seminal discoveries identified a novel mechanism of post-transcriptional gene regulation that has been recognized as important for development, physiology and pathology of many organisms. Here we discuss how functional genomic, computational and proteomic approaches complement classical genetic analyses to unravel miRNA biology in C. elegans.

Keywords: C. elegans, miRNA, microRNA, proteomics, SILAC, Argonaute, Ago, post-transcriptional gene regulation, let-7, lsy-6


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