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Editorial
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The final issue of Briefings in Functional Genomics and Proteomics this year contains a broad mix of articles covering microscopy, microarrays, HPLC for proteomics, transcriptional silencing and data integration. In our first article, Goran Mitulovic reviews recent advances in chromatographic techniques for proteomic analysis. One of the difficulties associated with the proteome is the separation of complex protein mixtures, and the subsequent identification of the individual components. One approach is to use two-dimensional gel electrophoresis to separate protein spots followed by detection using