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Briefings in Functional Genomics and Proteomics Advance Access originally published online on February 22, 2006
Briefings in Functional Genomics and Proteomics 2006 5(1):62-65; doi:10.1093/bfgp/ell001
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© Oxford University Press, 2006, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Special Issues Papers

Multi-protein complexes at the ß-globin locus

Milind C. Mahajan and Sherman M. Weissman

Corresponding author. Sherman M. Weissman, Department of Genetics, The Anlyan Center, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06510, USA. Tel: +1 203 737 2281/82; Fax: +1 203 737 2286. E-mail: Sherman.weissman{at}yale.edu

Biochemical analysis of the ß-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the ß-globin gene expression.

Keywords: ß-globin, LCR, SWI/SNF, MeCP1, CTCF, hnRNP C1/C2, GATA-1, NF-E2, EKLF


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