Briefings in Functional Genomics and Proteomics Advance Access originally published online on February 22, 2006
Briefings in Functional Genomics and Proteomics 2006 5(1):62-65; doi:10.1093/bfgp/ell001
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Special Issues Papers |
Multi-protein complexes at the ß-globin locus
Corresponding author. Sherman M. Weissman, Department of Genetics, The Anlyan Center, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06510, USA. Tel: +1 203 737 2281/82; Fax: +1 203 737 2286. E-mail: Sherman.weissman{at}yale.edu
Biochemical analysis of the ß-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the ß-globin gene expression.
Keywords: ß-globin, LCR, SWI/SNF, MeCP1, CTCF, hnRNP C1/C2, GATA-1, NF-E2, EKLF
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