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Briefings in Functional Genomics and Proteomics Advance Access originally published online on February 20, 2006
Briefings in Functional Genomics and Proteomics 2006 5(1):37-42; doi:10.1093/bfgp/ell006
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© Oxford University Press, 2006, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Special Issues Papers

A-to-I editing of the 5HT2C receptor and behaviour

Katheleen Gardiner and Yunzhi Du

Corresponding author. Katheleen Gardiner, Eleanor Rosssevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA. Tel: +1 303 336 5652; Fax: +1 303 333 8423; E-mail: kgardine{at}du.edu

Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties. Because serotonin functions in the regulation of mood and behaviour, modulation of serotonin signalling by RNA editing may be relevant to such psychiatric disorders as anxiety and depression. Several recent human studies have reported changes in 5HT2CR editing in schizophrenia, major depression or suicide, but results are variable and not conclusive. Rodent studies have begun to examine effects of drug treatments and stress. Understanding the importance of 5HT2CR editing in mood and behaviour will be assisted by experiments designed to analyse multiple strains of mice, in different behavioural tests, with optimal evaluation of the time course of molecular changes.

Keywords: serotonin signalling, protein isoforms, RNA editing, mouse strain, psychiatric disorder


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