Briefings in Functional Genomics and Proteomics Advance Access originally published online on September 2, 2006
Briefings in Functional Genomics and Proteomics 2006 5(3):177-178; doi:10.1093/bfgp/ell031
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Editorial
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How does one package several meters of rope into a poppy seed? Eukaryotic cells face a similar problem when packaging their genomic DNA, which can be several meters long, into the small dimensions of the nucleus. Cells have solved this problem by compacting genomic DNA through the association of DNA with proteins, mainly histones, into a refined DNA-protein complex termed chromatin. Histones are the basic packaging material for DNA and the building blocks of the nucleosome, the smallest structural unit