Skip Navigation



Briefings in Functional Genomics and Proteomics Advance Access published online on March 11, 2009
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/elp002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
8/1/60    most recent
elp002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Meyer, M.
Right arrow Articles by Vilardell, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyer, M.
Right arrow Articles by Vilardell, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing

Markus Meyer and Josep Vilardell

Corresponding author. Josep Vilardell, Gene Regulation Program, Centre de Regulació Genòmica, Dr Aiguader 88, 08003 Barcelona, Spain. Tel: +34-93-316-0116, Fax: +34-93-316-0099, E-mail: josep.vilardell{at}crg.es

Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA–protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression.

Keywords: regulated splicing, RNA, yeast, genomics, microarrays


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.