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Briefings in Functional Genomics and Proteomics Advance Access published online on October 29, 2007
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/elm022
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© Oxford University Press, 2007, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

EUCOMM—the European Conditional Mouse Mutagenesis Program

Roland H. Friedel, Claudia Seisenberger, Cornelia Kaloff and Wolfgang Wurst

Corresponding author. Wolfgang Wurst, GSF–National Research Center for Environment and Health, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. Tel: +49 89 3187 4110; Fax: +49 89 3187 3099; E-mail: wurst{at}gsf.de

Functional analysis of the mammalian genome is an enormous challenge for biomedical scientists. To facilitate this endeavour, the European Conditional Mouse Mutagenesis Program (EUCOMM) aims at generating up to 12 000 mutations by gene trapping and up to 8000 mutations by gene targeting in mouse embryonic stem (ES) cells. These mutations can be rendered into conditional alleles, allowing Cre recombinase-mediated disruption of gene function in a time- and tissue-specific manner. Furthermore, the EUCOMM program will generate up to 320 mouse lines from the EUCOMM resource and up to 20 new Cre driver mouse lines. The EUCOMM resource of vectors, mutant ES cell lines and mutant mice will be openly available to the scientific community. EUCOMM will be one of the cornerstones of an international effort to create a global mouse mutant resource.

Keywords: mouse mutagenesis, gene trap, gene targeting, conditional allele


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