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Briefings in Functional Genomics and Proteomics Advance Access published online on March 12, 2007
Briefings in Functional Genomics and Proteomics, doi:10.1093/bfgp/elm001
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© Oxford University Press, 2007, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Advances in neuromembrane proteomics: efforts towards a comprehensive analysis of membrane proteins in the brain

Kathleen J. Grant and Christine C. Wu

Corresponding author. Christine C. Wu, Department of Pharmacology, University of Colorado School of Medicine, Fitzsimons RC1 South, L18-6117, P.O. Box 6511, Mail Stop 8303, Aurora CO 80045, USA. Tel: +1-303-724-3351; E-mail: christine.wu{at}uchsc.edu

Proteomic investigation of normal and diseased brain states has the potential to reveal novel molecular therapeutic and diagnostic targets for a multitude of pathological central nervous system conditions. Due to their unique properties, integral membrane proteins are likely to play a central role in the aetiology of these disorders. These properties, however, have prevented comprehensive analysis of this important class of proteins. Recent advances in sample preparation and proteomic quantification platforms, specifically focused on recovery and enrichment of integral membrane proteins, are discussed.

Keywords: membrane proteins, mass spectrometry, neuroproteomics, proteomics, brain, quantification, sample preparation


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