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Briefings in Functional Genomics Advance Access originally published online on September 3, 2009
Briefings in Functional Genomics 2009 8(6):493-501; doi:10.1093/bfgp/elp036
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Non-Coding RNAs [View the issue table of contents]

Special Issue Papers

Retrotransposons and non-protein coding RNAs

Tobias Mourier and Eske Willerslev

Corresponding author. Tobias Mourier, Natural History Museum of Denmark, University of Copenhagen, Universitetsparken 15, DK-2100 Copenhagen, Denmark. Tel: +45 3532 1236; Fax: +45 3532 1300; E-mail: tmourier{at}snm.ku.dk

Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.

Keywords: transposable elements, RNA genes, gene regulation


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