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Briefings in Functional Genomics Advance Access originally published online on July 29, 2009
Briefings in Functional Genomics 2009 8(6):472-481; doi:10.1093/bfgp/elp024
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Non-Coding RNAs [View the issue table of contents]

Special Issue Papers

Deciphering the diversity of small RNAs in plants: the long and short of it

Frank Schwach, Simon Moxon, Vincent Moulton and Tamas Dalmay

Corresponding author. Frank Schwach, School of Computing Sciences, University of East Anglia, Norwich, UK. Tel: +44 (0)1603 59 2405; Fax: +44 (0)1603 593345; E-mail: f.schwach{at}uea.ac.uk

RNA silencing is a complex and highly conserved regulatory mechanism that is now known to be involved in such diverse processes as development, pathogen control, genome maintenance and response to environmental changes. Since its recent discovery, RNA silencing has become a fast moving key area of research in plant and animal molecular biology. Research in this field has greatly profited from recent developments in novel sequencing technologies that allow massive parallel sequencing of small RNA (sRNA) molecules, the key players of all RNA silencing phenomena. As researchers are beginning to decipher the complexity of RNA silencing, novel methodologies have to be developed to make sense of the large amounts of data that are currently being generated. In this review we present an overview of RNA silencing pathways in plants and the current challenges in analysing sRNA data, with a special focus on computational approaches.

Keywords: RNA silencing, bioinformatics, high-throughput sequencing, plant molecular biology


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