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Briefings in Functional Genomics 2009 8(6):444-450; doi:10.1093/bfgp/elp042
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Non-Coding RNAs [View the issue table of contents]

Special Issue Papers

The use of covariance models to annotate RNAs in whole genomes

Paul P. Gardner

Corresponding author. Paul P. Gardner, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Tel: +44 (0) 1223 494726; Fax: +44 (0) 1223 494 010; E-mail: pg5{at}sanger.ac.uk

In this review we discuss bioinformatic issues in non-coding RNA analysis, in particular the annotation of genome sequences using covariance models. Some recent innovations for improving the speed and accuracy of covariance models is discussed.

Keywords: ncRNA, Rfam, Covariance Models


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