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Briefings in Functional Genomics 2009 8(6):424-436; doi:10.1093/bfgp/elp037
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Non-Coding RNAs [View the issue table of contents]

Special Issue Papers

Establishing legitimacy and function in the new transcriptome

Harm van Bakel and Timothy R. Hughes

Corresponding author. Timothy R. Hughes, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada. Tel: +1-416-946-8260; Fax: +1-416-978-8287; E-mail: t.hughes{at}utoronto.ca

The last decade has seen an explosion of interest in new classes of non-coding RNA. While some are now firmly established as new categories of legitimate functional RNAs, the purpose and even existence of others remain to be solidified. Here, we discuss the challenges associated with discovery and characterization of non-traditional categories of non-coding RNA.

Keywords: transcription, noncoding RNA, tiling arrays, hidden transcriptome, RNA-seq


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