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Briefings in Functional Genomics and Proteomics 2009 8(4):276-282; doi:10.1093/bfgp/elp032
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Non-Coding Regulatory Regions in Genomes [View the issue table of contents]

Special Issue Papers

Chromatin insulators: lessons from the fly

B. V. Gurudatta and Victor G. Corces

Corresponding author. Victor G. Corces, Department of Biology, Emory University, 1510 Clifton Rd NE, Atlanta, GA 30322, USA. Tel: 404 727 4234; Fax: 404 727 2880; E-mail: vcorces{at}emory.edu

Chromatin insulators are DNA–protein complexes with broad functions in nuclear biology. Drosophila has at least five different types of insulators; recent results suggest that these different insulators share some components that may allow them to function through common mechanisms. Data from genome-wide localization studies of insulator proteins indicate a possible functional specialization, with different insulators playing distinct roles in nuclear biology. Cells have developed mechanisms to control insulator activity by recruiting specialized proteins or by covalent modification of core components. Current results suggest that insulators set up cell-specific blueprints of nuclear organization that may contribute to the establishment of different patterns of gene expression during cell differentiation and development.

Keywords: Drosophila, insulator, transcription, nucleus


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