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Briefings in Functional Genomics 2009 8(3):194-198; doi:10.1093/bfgp/elp028
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© The Author 2009. Published by Oxford University Press. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: The Future of Microarrays in an age of high throughput sequencing [View the issue table of contents]

Special Issue Papers

Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases

Mina Ryten, Danyah Trabzuni and John Hardy

Corresponding author. John Hardy, Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, Queen Square, London, WC1N 3BG, UK. E-mail: j.hardy{at}ion.ucl.ac.uk

Over the last year, many reliable genetic associations with complex diseases have been reported including some associations with complex neurological and psychiatric diseases. Many of these disease associations do not map to coding changes in protein open reading frames, but rather are believed to lead to genetic variability in gene expression and splicing. Such effects can be dissected by studies, which use genetic variability in mRNA expression as quantitative traits and regress these traits against genotype.


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