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Briefings in Functional Genomics 2008 7(6):444-453; doi:10.1093/bfgp/eln049
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Transposon tools hopping in vertebrates

Jun Ni, Karl J. Clark, Scott C. Fahrenkrug and Stephen C. Ekker

Corresponding author. Stephen C. Ekker, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Tel: 507-284-5530; Fax: 507-284-9349; E-mail: ekker.stephen{at}mayo.edu

In the past decade, tools derived from DNA transposons have made major contributions to vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish genetic manipulation to human gene therapy is currently a complex task. We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.

Keywords: transposon, gene delivery, gene discovery, gene transfer vectors, vertebrates


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