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Briefings in Functional Genomics Advance Access originally published online on October 4, 2008
Briefings in Functional Genomics 2008 7(6):415-426; doi:10.1093/bfgp/eln044
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Medaka genome project

Daisuke Kobayashi and Hiroyuki Takeda

Corresponding author. Daisuke Kobayashi, Department of Anatomy and Developmental Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan. Tel: +81-75-251-5302; Fax: +81-75-231-5304; E-mail: kdaisuke{at}koto.kpu-m.ac.jp

The medaka Oryzias latipes is a small egg-laying freshwater teleost, and has become an excellent model system for ecotoxicology, developmental genetics, genomics and evolutionary biology studies. A high-quality draft genome sequence (700 Mb) of the medaka inbred strain, Hd-rR, has now been completed. In this review, we present an overview of the medaka genome project and describe the substantial genomic resources and genome browsers through which researchers can now freely access these resources. We also present specific findings that have been obtained using these tools, such as sex chromosome differentiation, gene prediction and gene evolution.

Keywords: Whole genome shotgun, mutant, sex chromosome, SNP, evolution


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