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Briefings in Functional Genomics 2008 7(5):355-370; doi:10.1093/bfgp/eln041
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Functional Genomics and Proteomics issue: Special Issue: Topics in quantitative biological mass spectrometry [View the issue table of contents]

Special Issue Papers

Quantitative matrix-assisted laser desorption/ionization mass spectrometry

Mark W. Duncan, Heinrich Roder and Stephen W. Hunsucker

Mark W. Duncan, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver, Mail Stop 8106, 12801 East 17th Avenue, Aurora, CO 80045, USA. Tel: (303) 724-3343; Fax: (303) 393-5271; E-mail: mark.duncan{at}ucdenver.edu

This review summarizes the essential characteristics of matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS), especially as they relate to its applications in quantitative analysis. Approaches to quantification by MALDI-TOF MS are presented and published applications are critically reviewed.

Keywords: quantification, quantitative analysis, MALDI, mass spectrometry, biomarkers


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