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Briefings in Functional Genomics Advance Access originally published online on February 24, 2006
Briefings in Functional Genomics 2006 5(1):66-73; doi:10.1093/bfgp/ell013
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© Oxford University Press, 2006, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Special Issues Papers

Organization of brain complexity—synapse proteome form and function

A. J. Pocklington, J. D. Armstrong and S. G. N. Grant

Corresponding author. Dr S. G. N. Grant, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK. Tel: +44 1223 494908; Fax: +44 1223 494919. E-mail: sg3{at}sanger.ac.uk

Proteomic study of the synapse has generated an extensive list of molecular components, revealing one of the most complex functional systems currently known to cell biology. While fundamental to neural information processing, behaviour and disease, the molecular organisation of the synapse and its relation to higher-level function has yet to be clearly understood. Neurotransmitter receptor complexes, such as the N-methyl-D-aspartate receptor complex (NRC/MASC), are major components of the synaptic proteome. We have recently completed a detailed study of MASC, its functional organisation and involvement in behaviour and disease. This pointed to simple design principles underlying synaptic organisation. Drawing together the results of proteomic and analytical study, we sketch out a model for synaptic functional organisation.

Keywords: LTP, NMDA receptor, protein complex, synaptic plasticity, networks


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