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Briefings in Functional Genomics and Proteomics Advance Access originally published online on February 20, 2006
Briefings in Functional Genomics and Proteomics 2006 5(1):4-7; doi:10.1093/bfgp/ell005
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© Oxford University Press, 2006, All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Special Issues Papers

Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene products

Takahiro Nagase, Hisashi Koga and Osamu Ohara

Corresponding author. Osamu Ohara, PhD, Department of Human Gene Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan. Tel: +81-438-52-3913; Fax: +81-438-52-3914; E-mail: ohara{at}kazusa.or.jp

The Kazusa cDNA project pioneered an extensive sequencing project of human cDNAs in their entirety and focused sequencing efforts particularly on large cDNAs encoding large proteins. More than 2000 human genes, referred to as ‘KIAA’ genes, were initially identified through this cDNA project. Since many KIAA genes still remain functionally uncharacterized, our current focus is to determine their biological functions in vivo. In this review, we describe the current status of the Kazusa mammalian cDNA resources and the future direction of the functional characterization of KIAA genes.

Keywords: cDNA analysis, ORF cloning, antibody production, recombinant protein production, database


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