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Briefings in Functional Genomics and Proteomics 2004 2(4):344-354; doi:10.1093/bfgp/2.4.344
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© Henry Stewart Publications

Chromatin remodelling and the interaction between enhancers and promoters in the ß-globin locus

Ann Dean
Senior investigator in the Laboratory of Cellular and Developmental Biology at the National Institute of Diabetes, Digestive and Kidney Diseases.


Ann Dean, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 50, Room 3154, 50 South Drive, MSC 8028 Bethesda, MD 20892, USA Tel: +1 301 496 6068 Fax: +1 301 496 5239 E-mail: anndean{at}helix.nih.gov

The ß-globin genes are among the most studied families of tissue-specific and developmentally regulated genes. Even before genome-wide sequencing was a reality, the sequences of extensive regions of the human, rabbit and mouse ß-globin loci were available through the individual efforts of several research groups. Many of the genomic approaches now being pursued in order to understand the control of gene expression were applied early to this gene family with success. Higher levels of regulation attributable to networks of transcription factor interaction, chromatin remodelling and enhancer—promoter communication remain as challenges in the post-genomic era.

Keywords: globin genes, locus control regions, chromatin remodelling, enhancers


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