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Briefings in Functional Genomics and Proteomics 2004 2(4):334-343; doi:10.1093/bfgp/2.4.334
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© Henry Stewart Publications

Chromatin higher order structure: Opening up chromatin for transcription

Attila Németh
Holds a postdoctoral fellowship in Gernot Längst's group. His research interests include the regulation of ribosomal gene transcription in chromatin.

Gernot Längst
Group leader in the Divison of Molecular Biology at the Adolf-Butenandt-Institute of the Ludwig Maximilian University in Munich. His research interests include the molecular mechanisms of chromatin dynamics and gene regulation in chromatin.


Gernor Längst, Adolf-Butenandt-Institut, Molekularbiologie, Schillerstraße 44, 80336 München, Germany Tel: +49 89 5996 435 Fax: +49 89 5996 425 E-mail: laengst{at}lmu.de

DNA packaged into chromatin is the physiologically relevant substrate for all DNA-dependent processes inside the nuclei of eukaryotic cells. The highly compacted structures of DNA and histones is inherently repressive for all DNA-dependent processes. Active mechanisms exist to generate dynamic chromatin, which maintains two apparently contradictory functions: tight compaction and free accessibility of DNA. The dynamics of chromatin higher order folding and the influence of chromatin structure on transcription will be described in this paper. Chromatin dynamics and higher order folding may be the key regulators of not only transcription but of all DNA-dependent processes in the nucleus.

Keywords: chromatin, remodelling, transcription


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