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Briefings in Functional Genomics and Proteomics 2004 2(4):320-333; doi:10.1093/bfgp/2.4.320
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© Henry Stewart Publications

Identification and characterisation of imprinted genes in the mouse

Jo Peters
Leads the imprinting programme at the MRC Mammalian Genetics Unit, Harwell, and has a particular interest in the imprinted Gnas complex locus.

Colin Beechey
Long-standing interest in mouse genetics and cytogenetics and, with Bruce Cattanach and colleagues, has defined regions of the mouse genome subject to imprinting. This work resulted in the Harwell Mouse Imprinting Map and Website.


Jo Peters, Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxon OX11 0RD, UK Tel: +44 (0) 1235 841000 Fax: +44 (0)1235 824530 E-mail: j.peters{at}har.mrc.ac.uk

Imprinted genes are expressed specifically from one or other parental allele. Over 70 are now known, and about one-half of these are expressed from the paternal allele and one-half from the maternal allele. Most imprinted genes are clustered within imprinting regions of the mouse genome, regions which are associated with abnormal phenotypes when inherited uniparentally. Imprinted genes have been identified from surveys based on differential expression or differential methylation according to parental origin, as well as analyses of candidate genes, mutants and imprinted gene clusters. Many imprinted genes affect growth and development, and more than 25 per cent determine non-coding RNAs that may have a function in controlling imprinted gene expression.

Keywords: imprinting, epigenetics, differential expression, differential methylation, non-coding RNAs


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