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Briefings in Functional Genomics and Proteomics 2004 2(4):308-319; doi:10.1093/bfgp/2.4.308
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© Henry Stewart Publications

Cell-free protein synthesis for proteomics

Alison M. Jackson
Senior scientist at Discerna Ltd, which is a drug discovery company using cell-free protein display and microarray technologies to develop human antibody therapeutics.

Joe Boutell
Senior scientist at Discerna Ltd.

Neil Cooley
Senior scientist at Discerna Ltd.

Mingyue He
Chief Scientific Officer at Discerna Ltd.


Mingyue He, Discerna Ltd., Babraham Research Campus, Babraham, Cambridge CB2 4AT, UK Tel: +44 (0) 1223 496249 Fax: +44 (0) 1223 496038 E-mail: m.he{at}discerna.co.uk

The use of cell-free expression systems as an alternative to cell-based methods for protein production is greatly facilitating studies of protein functions. Recent improvements to cell-free systems, and the development of cell-free protein display and microarray technologies, have led to cell-free protein synthesis becoming a powerful tool for large-scale analysis of proteins. This paper reviews the most commonly used cell-free systems and their applications in proteomics.

Keywords: cell-free protein synthesis, proteomics, cell-free protein display and microarrays, in vitro transcription and translation


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