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Briefings in Functional Genomics and Proteomics 2004 2(4):298-307; doi:10.1093/bfgp/2.4.298
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© Henry Stewart Publications

Modelling the fission yeast cell cycle

Akos Sveiczer
A Reader in the Department of Agricultural Chemical Technology at Budapest University of Technology and Economics.

John J. Tyson
A University Distinguished Professor in the Department of Biology at Virginia Polytechnic Institute and State University.

Bela Novak
A professor in both the Department of Agricultural Chemical Technology at Budapest University of Technology and Economics, and the Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences.


Akos Sveiczer, 1111 Budapest, Szt. Gellert ter 4, Hungary Tel: +36 1 463 2349 Fax: +36 1 463 2598 E-mail: asveiczer{at}mail.bme.hu

The molecular networks regulating basic physiological processes in a cell can be converted into mathematical equations (eg differential equations) and solved by a computer. The division cycle of eukaryotic cells is an important example of such a control system, and fission yeast is an excellent test organism for the computational modelling approach. The mathematical model is tested by simulating wild-type cells and many known cell cycle mutants. This paper describes an example where this approach is useful in understanding multiple rounds of DNA synthesis (endoreplication) in fission yeast cells that lack the main (B-type) mitotic cyclin, Cdc13. It is proposed that the key physiological variable driving progression through the cell cycle during balanced growth and division is the mass/DNA ratio, rather than the mass/nucleus ratio.

Keywords: functional proteomics, cell cycle, fission yeast, mathematical modelling, molecular network, endoreplication


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